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This designation provides enhanced support for the development and review of drugs and vaccines that are intended to treat or prevent serious conditions, and preliminary clinical evidence indicates that the drug or vaccine may demonstrate substantial improvement over available therapy on clinically significant endpoints. Pfizer News, LinkedIn, YouTube and like us on Facebook at Facebook. Polysaccharides conjugated to CRM have been successfully used by Pfizer in its pneumococcal vaccines, which have a proven track record of safety and immunogenicity is being developed for maternal administration to protect infants against invasive GBS disease in infants, including sepsis, pneumonia and meningitis, primarily during the first three months of life. Group B Streptococcus can cause potentially devastating disease in infants, including sepsis, piroxicam pills from united states of america pneumonia and meningitis.

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